
The dominant Czech fifth seed fired 11 aces and wrapped up the match in an hour and 56 minutes to halt Vandeweghe’s fine run in the clay-court tournament at Stuttgart.
The 26-year-old Vandeweghe beat world number one Simona Halep and US Open champion Sloane Stephens earlier in the tournament, but could not find a way past Plíšková.
“It’s the best atmosphere to play in Germany,” Plíšková said after the match. “I want to thank my team. I think we had a great week, and without them, I would not have the trophy.”
Former world number one Pliskova trailed 2-0 in the tiebreak at the end of a tight first set but reeled off seven points in a row for an early advantage in the contest.
After Vandeweghe called for the trainer following a tumble early in the second set, Plíšková raised her level and broke her bruised opponent’s serve to go up 3-2.
Plíšková saved a breakpoint in the next game to increase her lead. She then broke Vandeweghe again to make it 5-2 before the American attempted a late fightback with a break of her own.
Plíšková, however, maintained focus to serve out the match.
Victory in Stuttgart gave world number six Plíšková a 10th career title and her first since winning the trophy in Eastbourne last year.