
Alaska state police said a Bering Air Caravan with nine passengers and one pilot onboard was reported overdue on a flight from Unalakleet to Nome at 4pm Alaska standard time.
The two cities are located roughly 235km apart from each other across the Norton Sound.
Search and rescue crews “are working to get to the last known coordinates” of the flight, authorities said in a statement.
The missing flight is the latest incident in a recent string of aviation disasters in the US.
On Jan 30, a passenger jet collided mid-air with a US army helicopter in the capital city of Washington, killing all 67 people aboard.
The disaster was followed closely by the crash of a medical plane into a busy Philadelphia neighbourhood, killing seven and injuring 19.