Ground staff spent hours working to dry the wet outfield at Lauderhill but shortly after the umpires had inspected conditions a huge downpour ended any hope with the field quickly under water once again.
The US reach the last eight in their debut appearance in the T20 World Cup largely thanks to their shock win over 2009 champions Pakistan.
A US defeat to Ireland would have handed Pakistan the chance to leapfrog into the top two when they face Ireland at the same venue on Sunday.
Instead, the early exit is a bitter disappointment for Pakistan, who were beaten finalists in the tournament two years ago.
This is the earliest Pakistan have exited T20 World Cup, having played just three games with a defeat to India and their sole victory coming against Canada.
Pakistan were knocked out in the group stage in 2014 and 2016, but on every other occasion made it to the last four of the tournament.
Fans who had waited patiently inside the Central Broward Stadium were instructed to stay in the facility and in shelter due to thunder and lightning which accompanied the torrential rain.
The two teams will receive a point each meaning the US will progress to the Super Eights along with Group A winners India who are due to play Canada on Saturday in what is now a dead rubber
South Florida has suffered heavy rain and flooding and the game on Tuesday at Lauderhill between Sri Lanka and Nepal was also abandoned.
There were heavy showers earlier on Friday morning which added to the workload which all proved to be in vain.
But while it was not the way they wanted to qualify, the US team celebrated in their locker-room what is a historic achievement for the associate nation.
“As a cricketer, you don’t want to leave home and not play cricket, you want to play but at the end of the day there was nothing that we could control,” said US vice-captain Aaron Jones, who was again stand-in skipper in the absence of the injured Monank Patel.
“Definitely we celebrated. Everybody is happy right now, obviously qualifying for the Super Eights is a big deal,” added Jones, who has been the stand-out batter for the US team.
Jones was vocal before the tournament in insisting the US were not just happy to be involved but believed they could win games and he said that attitude would continue against the tougher opponents that await.
“I think that on any given day, once we play proper cricket that we can beat any team in the world,” said the New York born Jones, who grew up in Barbados and will return to the Caribbean for the next round of games.
The spot in the last eight also means that the US have qualified automatically for the 2026 World Cup.