According to the Penang Health Department, 1,832 cases were recorded in the state as of July 15.
This represented a 71.2% increase compared to 1,070 cases recorded during the same period last year.
The department said four new HFMD clusters were recorded on Friday and Saturday, bringing the current total to 80.
Six HFMD patients were still being warded at three different hospitals in the state.
A total of 23 premises, including primary schools, nurseries and kindergartens remained shut.
HFMD is caused by a viral infection specifically from the Coxsackie A16 and Enterovirus 71 (EV71) types and spreads through contact with saliva and faeces from patients.
The infections are usually mild with fever symptoms, followed by blisters on the hands, feet, mouth and tongue.
The department urged childcare operators to report any HFMD outbreak to the health district offices.
Penang records 48% rise in hand, foot and mouth disease cases