“Undocking confirmed! @SpaceX’s CRS-29 Dragon is currently en route to Earth, set to splash down off the coast of Florida,” Nasa said on X, formerly known as Twitter.

The spacecraft is carrying about 1,995kg of “precious scientific cargo” back to Earth, “including data assessing how cells respond to gravity, plants’ genetic adaptations in space, and more,” the space agency added.

The spacecraft is expected to land off the coast of Florida this morning, Nasa said.

Northrop Grumman’s uncrewed Cygnus spacecraft is also expected to depart the ISS today around 7.45am local time. Unlike the Dragon spacecraft, Cygnus will safely burn up in Earth’s atmosphere, according to Nasa.

The 29th SpaceX resupply mission to the ISS docked at the station on Nov 11 and brought 2948kg of cargo, including new scientific investigations to study atmospheric gravity waves and test high data rate laser communications from the space station to Earth, as well as provisions for the crew.