
Nigeria face Gabon in the first semi-final on Nov 13 in a match-up set to feature two star strikers, Turkey-based Victor Osimhen and Pierre-Emerick Aubameyang of Marseille.
An Osimhen hat-trick against Rwanda in a group match this month helped Nigeria squeeze into the play-offs on goal difference at the expense of Burkina Faso.
Later on Nov 13, at a different venue, DR Congo face Cameroon, whose eight World Cup appearances are an African record.
This semi-final is likely to involve Manchester United striker Bryan Mbeumo, whose brace against Brighton last weekend helped lift the Red Devils to sixth in the Premier League.
DR Congo are hoping to qualify a second time. The country was called Zaire when they featured in the 1974 World Cup and suffered three losses, including a 9-0 thrashing by Yugoslavia.
The mini-tournament winners advance to six-nation intercontinental play-offs next March at a venue to be confirmed. Two places at the World Cup in the US, Canada and Mexico will be up for grabs.
Bolivia and New Caledonia have secured places at the tournament, Iraq or the UAE will represent Asia, and Curacao and Costa Rica are the frontrunners to fill the two Caribbean/Central American slots.