“Huijsen arrived with symptoms of muscular fatigue at the Spain national team camp on Monday night,” said the Spanish football federation in a statement.

“On Tuesday he did not train… and on Wednesday he had a medical test confirming a muscular injury, which Real Madrid have been informed of.”

The 20-year-old centre-back joined Los Blancos from Premier League club Bournemouth this summer and made his Spain debut in March in the Nations League.

Laporte, who recently rejoined Athletic Bilbao, was a key part of the Spain squad that won Euro 2024.

Barcelona winger Lamine Yamal and Man City midfielder Rodri Hernandez previously withdrew injured from the squad for the games against Georgia and Bulgaria on Saturday and Oct 14 respectively.

Spain lead Group E after beating Bulgaria and Turkey in their opening qualifiers for next summer’s tournament in the US, Mexico and Canada.