
The victory also moves Djokovic into his 64th Grand Slam quarter-final, extending his all-time record, and keeps alive his pursuit of a record 25th major title.
Djokovic dominated from the opening game, breaking the 35-year-old German’s serve six times during the 109-minute match.
Struff, ranked No 144 in the world, had defeated three seeded players to reach his first US Open fourth round but was unable to put any serious pressure on the Serb.
Djokovic required treatment from the physio on his right shoulder and forearm during changeovers but did not appear overly troubled by the issues and won 79% of his first-serve points.