Two second half goals in a minute from Yuya Kuwasaki and Koya Yuruki added to Yoshinori Muto’s 11th-minute strike to give Vissel a deserved 3-0 lead.
Vissel’s Yuya Osako saw his penalty saved in the 78th minute but swept home three minutes later from a freekick to complete the scoring and put Kobe top of the 12-team league with 16 points.
The top eight advance to the knockouts.
It was a great Matchday 7 for Japan as all three of their representatives in Asia’s premier club competition reached the last 16.
Kawasaki Frontale sealed their passage with a comfortable 4-0 win at South Korea’s Pohang Steelers.
Shin Yamada gave Frontale a 38th-minute lead before second half strikes from Yasuto Wakizaka, So Kawahara and Erison secured the points.
The third Japanese representative, last year’s beaten finalists Yokohama F Marinos, play tomorrow but progressed without kicking a ball on 13 points courtesy of today’s results.
Also through are South Korea’s Gwangju, who also have 13 points and were playing at China’s Shandong Taishan later.
Malaysia’s Johor Darul Ta’zim put one foot in the last 16 with a 2-1 win at Australia’s rock-bottom Central Coast Mariners, who have only one point from seven matches.
Alvaro Gonzalez was the hero for the visitors, scoring two second half goals either side of Alou Kuol’s equaliser.
Mariners played the whole of the second half with 10 men after 18-year-old goalkeeper Dylan Peraic-Cullen was red-carded for scything through Arif Aiman just outside the box in first half injury-time.
Johor are on 11 points and look almost certain to progress to the last 16, needing just a draw at home to Pohang Steelers next week to be certain.
However, they could lose and still go through if other results go their way.
The West Zone teams have already played seven matches, with Cristiano Ronaldo’s Al Nassr and the other star-studded Saudi Arabian sides – Al Ahli and Al Hilal – already reaching the last 16.
The final round of league fixtures takes place in both zones next week.
The last 16 matches will be played over two legs in March.
Saudi Arabia will then host the quarterfinals, semifinals and final from April 25 to May 4.