
A polished Wang bested the two-time major winner in lengthy exchanges to extend her deepest ever run at a Grand Slam.
Azarenka, a three-time US Open runner-up, committed 32 unforced errors and dropped serve six times in the two hour 22 minute battle.
The Belarusian former world No 1 saw an early 3-1 first-set lead erode as Wang rallied back to take the opener with a cross-court forehand blast that the two-time Australian Open champion sent long.
Azarenka, who beat Wang at the Washington Open a month ago, made her greater experience count as she rattled off four straight games in the second set to force a decisive final frame.
But a jubilant crowd packed with Chinese fans, still buzzing from Zheng Qinwen’s win in the prior match on Grandstand, cheered on 80th ranked Wang as she opened up a 4-0 lead in third set before securing victory.