Spanish side Barcelona met the 2017 Europa League winners twice in the 2009 and 2011 Champions League finals, winning on both occasions, while United lost both legs of the 2018-19 European Cup quarterfinal meeting between the pair.

United finished second in their Europa League group this season behind another Spanish team – Real Sociedad – and meet a Barca side that missed out on the Champions League last 16 after finishing third in their group behind Bayern Munich and Inter Milan.

The eight group runners-up from the Europa League face eight third-placed sides from the Champions League group stages, with the winners of the two-legged playoffs progressing to the last 16.

The pick of the other ties sees six-time winners Sevilla facing Dutch side PSV Eindhoven, Serie A giants Juventus take on Ligue 1 team Nantes, while Jose Mourinho’s AS Roma face RB Salzburg.

The first legs of the ties will take place on Feb 16, with the return match a week later on Feb 23.

Draw in full:

Barcelona v Manchester United

Juventus v Nantes

Sporting Lisbon v Midtjylland

Shakhtar Donetsk v Stade Rennais

Ajax Amsterdam v Union Berlin

Bayer Leverkusen v AS Monaco

Sevilla v PSV Eindhoven

Salzburg v AS Roma