
Sakkari, a 2021 Roland Garros semifinalist, is the fifth women’s top 10 seed to lose in the first four days at Roland Garros.
Muchova has matched her run to the third round from 12 months ago and will next play 27th seed Amanda Anisimova, who reached the last four in Paris three years ago.
“It’s very special, she’s an amazing player. It was a big fight, a little bit of a test and challenge for me and I’m happy I took it the way I did,” said Muchova.
The 25-year-old reached the semifinals at last year’s Australian Open and the last eight for the second time at Wimbledon, but is playing just her fourth tournament since the US Open after struggling with an abdominal injury.
“It’s an amazing feeling I can play again fully.”