Benzema was looking for his 45th goal of the season but was twice denied by Osasuna goalkeeper Sergio Herrera, who both times dived to his right and both times made the save with Real leading 2-1 at El Sadar.

But Osasuna were unable to find an equaliser in the second half and Real added a third in injury-time, Vinicius Junior teeing up Lucas Vazquez for an easy finish.

David Alaba’s opener had earlier been cancelled out by Osasuna’s Ante Budimir, before Marco Asensio restored Real’s advantage on the stroke of halftime.

Real move 17 points clear at the top of La Liga, ahead of Atletico Madrid, who missed the chance to pull away in the race for the top four after being held to a goalless draw by Granada.

The stalemate means Atletico move up to second in the table but could be overtaken by both Barcelona and Sevilla on Thursday. Barca play at Real Sociedad after Sevilla travel to Levante.

Real Betis, who were beaten by Elche on Tuesday, are four points behind Atletico in fifth.

Real coach Carlo Ancelotti started Toni Kroos and Vinicius on the bench while Luka Modric was left out of the squad completely, with the first leg of their Champions League semifinal against Manchester City less than a week away.

Alaba put Real in front in the 13th minute, bundling in the rebound after Benzema had tapped the ball across, but the advantage was brief as Budimir knocked in Chimy Avila’s pass to the back post a minute later.

Real restored their lead at the end of the half as Asensio played inside from the right wing and continued his run into the penalty box. Eduardo Camavinga chipped to the left side of the box and while Dani Ceballos’ effort was saved, Asensio’s run was rewarded with a simple finish.

Benzema’s pair of penalties came in the 52nd and 59th minutes, both won by Rodrygo, whose sharp turn tempted Avila into a handball on the ground before Nacho Vidal stumbled into the back of the Brazilian.

At the first attempt, Benzema struck left but Herrera dived to make the save. The second time, Herrera pointed to Benzema’s right but Benzema opted for the same side, Herrera guessing correctly again to palm away to safety.

Vinicius came off the bench and should have added a third in injury-time but side-footed wide, before tearing away again and this time laying across for Vazquez to find the corner.

Atletico frustrated

Atletico had earlier been left frustrated by a goalless draw with Granada.

After six consecutive victories between February and April, Atletico have now managed just one win from their last five in all competitions, bringing back some of the concerns that hung over the team earlier in the season.

Without Joao Felix, who will miss the rest of the season through injury, La Liga’s reigning champions lacked the thrust needed to break down a determined Granada side, who was playing its first match under new coach Aitor Karanka.

Granada sit 18th, a point behind Cadiz, who have a game in hand.