
The Russian second seed triumphed 6-7 (5/7), 6-3, 6-4 over seventh seeded Hurkacz.
“I had zero breakpoints to save, so in a way I was never under pressure,” said US Open champion Medvedev who fired 15 aces in the match.
“I had only two games on Hubert’s serve where I had breakpoints. Super happy to make this work and that I managed to get both breaks.”
Hurkacz has enjoyed a breakout season, winning his first Masters event in Miami and making the semifinals at Wimbledon after beating Roger Federer in the last-eight.
He is appearing in the end-of-season showpiece for the first time.
“I’ll just try to stay positive,” he said.
“I lost this match, but I’ll think about the positives and what I can do better and prepare for the next one.”
Medvedev has now won 23 of his last 26 matches.
Later Sunday, sixth-seeded Matteo Berrettini of Italy saw his challenge suffer a painful end when injury forced him to retire against Alexander Zverev.
The German third seed was 7-6 (9/7), 1-0 ahead when Wimbledon runner-up Berrettini called it quits with an apparent abdomen strain.
“To be honest I feel like crying right now. I know Matteo so well and I just feel bad for him,” said Zverev.
This year’s ATP Finals are being played in Turin for the first time after being switched from London.
On Monday, world No 1 Novak Djokovic faces Casper Ruud while Stefanos Tsitsipas tackles Andrey Rublev.