A matchday-five home victory over Mamelodi Sundowns of South Africa would ensure two-time champions Wydad qualify from Group C with a game to spare.
Record eight-time champions Al Ahly of Egypt, MC Alger of Algeria, and Primeiro Agosto of Angola are the other sides in the running for last-eight slots.
Espérance and Étoile du Sahel of Tunisia, as well as TP Mazembe of the Democratic Republic of Congo – all former champions – have already booked places in the quarter-finals draw.
Ahly have won their last two away matches against great rivals Espérance, so they will be confident of improving on a goalless home draw against the Tunis outfit three months ago.
Both teams are in good form after back-to-back victories over Township Rollers of Botswana and Kampala Capital City Authority of Uganda respectively.
“My target is simply to win every match,” stressed recently appointed Patrice Carteron, the first French coach of the Cairo Red Devils.
With five-time champions Mazembe safely through, Algerian teams MC Alger and ES Sétif are fighting for second place, while winless Difaa el Jadida of Morocco bring up the rear.
Sétif have improved since a 4-1 matchday-one hiding in DR Congo and a point at home in the reverse fixture would keep them in contention.
MC Alger, who were crowned African champions 42 years ago, hope to at least draw in El Jadida before hosting Sétif later this month.
Wydad confront Sundowns in a clash of the last two CAF Champions League title-holders and tradition suggests a low-scoring affair in the Moroccan commercial capital.
They met in a 2017 quarterfinal with each club winning 1-0 at home before Wydad squeezed through on penalties, and they drew 1-1 in Pretoria last May.
Should the South Africans lose they are likely to be replaced in second place by Horoya of Guinea, who enjoy home advantage against strugglers Port of Togo.
If Primeiro want to reach the last eight with a match to spare, they will have to win at Étoile Sahel and bank on Zesco Untied of Zambia defeating Mbabane Swallows in eSwatini.
But given that the Angolans were held at home by the Tunisians and 2016 semifinalists Zesco have underperformed this season, it is an unlikely scenario.
A workmanlike Primeiro outfit coached by Serb Zoran Manojlović are still the likeliest team to join Étoile, though, as they host Swallows on the final matchday.