Playing in front of a sparsely populated Wanda Metropolitano, it took dominant Atlético until the 57th minute to extend their four-goal first-leg lead when Yannick Carrasco met Diego Costa’s cutback and slotted home the opener.
Kevin Gameiro tapped in the second 17 minutes later after a neat burst into the box from Ángel Correa, and Vitolo made it three nine minutes from the end, racing through and crashing home his first Atlético goal.
Valencia host Las Palmas at the Mestalla later with their tie level at 1-1.