Lilly drug slows Alzheimer’s by 60% for the mildly impaired

Lilly drug slows Alzheimer’s by 60% for the mildly impaired

Donanemab's effects continued to increase over the course of its 18-month trial.

The study results of Eli Lilly’s drug Donanemab will be presented at an Alzheimer’s conference today. (AP pic)
WASHINGTON:
Eli Lilly’s experimental drug Donanemab slowed the progression of Alzheimer’s by 60% for patients in the earliest stages of the brain-wasting disease, the Alzheimer’s Association said today in a press release.

For those patients, the drug slowed cognitive decline by nearly twice the rate Lilly reported in May for the trial’s overall treatment group.

Lilly’s drug, donanemab, like Eisai and Biogen’s recently approved Leqembi, is an intravenous antibody designed to remove deposits of a protein called beta amyloid from the brains of Alzheimer’s patients.

The Alzheimer’s Association said donanemab’s treatment effect continued to increase relative to placebo over the course of the 18-month trial.

Lilly said in May that the study had met all of its goals, showing that donanemab slowed cognitive decline by 29% compared to a placebo in 1,182 people with mild cognitive impairment or mild dementia whose brains had deposits of two key Alzheimer’s proteins, beta amyloid and tau.

The full study results are being presented at the Alzheimer’s Association International Conference in Amsterdam and published in JAMA on Monday.

The FDA this month granted standard approval to leqembi, the first Alzheimer’s disease modifying treatment to achieve that goal, clearing the way for wider insurance coverage of the drug.

Both medications are also being studied in large trials to see if they have an impact on delaying onset of Alzheimer’s disease symptoms.

More than six million Americans are living with Alzheimer’s, and that number is projected to rise to nearly 13 million by 2050, according to the Alzheimer’s Association.

Stay current - Follow FMT on WhatsApp, Google news and Telegram

Subscribe to our newsletter and get news delivered to your mailbox.